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CBT-201 (CommBio Therapeutics)
- Development stage
- Preclinical
- Lead developer
- CommBio Therapeutics
- Modality
- Synthetic Biology Platforms → Engineered Microbial Therapeutics → Microbiome Therapeutics, Fresh FMT → Fecal Microbiota Transplantation (FMT) → Microbiome Therapeutics, Yeast Strains → Single Strain Products → Live Biotherapeutic Products → Microbiome Therapeutics, Bacterial Strains → Single Strain Products → Live Biotherapeutic Products → Microbiome Therapeutics, Defined Consortia → Multi-strain Products → Live Biotherapeutic Products → Microbiome Therapeutics, Frozen FMT → Fecal Microbiota Transplantation (FMT) → Microbiome Therapeutics, Genetically Modified Bacteria → Engineered Microbial Therapeutics → Microbiome Therapeutics, Microbial Metabolites → Microbiome-Derived Products → Microbiome Therapeutics, Microbial Proteins → Microbiome-Derived Products → Microbiome Therapeutics, Complex Communities → Multi-strain Products → Live Biotherapeutic Products → Microbiome Therapeutics
- Administration
- Oral
01
Overview
CBT-201 is an engineered bacterial therapeutic being developed by CommBio Therapeutics for the management of hangovers and alcohol-related health issues. The drug consists of a live bacterial strain genetically modified to target and metabolize acetaldehyde, a toxic intermediate of alcohol metabolism that is primarily responsible for the physiological symptoms of a hangover and long-term alcohol-induced tissue damage. By degrading acetaldehyde within the gastrointestinal tract, CBT-201 aims to reduce the systemic absorption and overall burden of this toxin. The program has successfully completed the strain optimization phase and is currently progressing through IND-enabling studies.
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