CCNU + carbamazepine

CCNU + carbamazepine is a combination of two pharmaceutical agents used in clinical settings where both drugs are indicated. - **Lomustine (CCNU)** is an oral alkylating agent of the nitrosourea class primarily used as part of combination chemotherapy for primary and metastatic brain tumors and as secondary therapy for refractory or relapsed Hodgkin's disease. It acts by interfering with DNA and RNA function, leading to cell death in rapidly dividing cancer cells[2][5]. - **Carbamazepine** is an anticonvulsant and analgesic drug indicated for epilepsy (including partial seizures and generalized tonic-clonic seizures), trigeminal neuralgia pain, and bipolar disorder. It works mainly by inhibiting voltage-gated sodium channels in neuronal membranes, stabilizing hyperexcited nerve membranes[1]. When combined, these drugs may be co-administered in patients with brain tumors who also require seizure control; however, caution is warranted due to potential pharmacokinetic interactions—carbamazepine can induce hepatic enzymes that may alter the metabolism or toxicity profile of chemotherapeutic agents like lomustine[5][6].

Brand names

CeeNUTegretol

Other names

lomustine + carbamazepineCCNU + carbamazepine