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CD3ζ:MyD88 fusion protein
- Development stage
- Preclinical
- Lead developer
- University of Colorado Anschutz Medical Campus
- Modality
- Fc-Fusion Proteins → Carrier/Scaffold Proteins → Recombinant Proteins and Enzymes, Cell Therapies
- Administration
- Intravenous
01
Overview
CD3ζ:MyD88 fusion protein is a recombinant signaling construct designed for use in adoptive cell therapy (ACT), specifically for engineering tumor-infiltrating lymphocytes (TILs). The protein consists of the signaling domain of the CD3ζ chain, a critical component of the T-cell receptor (TCR) complex, fused to MyD88, a key adapter protein in the Toll-like receptor (TLR) and interleukin-1 receptor (IL-1R) pathways. This fusion allows for the activation of MyD88-mediated costimulatory signals in a TCR-dependent manner upon antigen recognition. Developed by researchers at the University of Colorado Anschutz Medical Campus, the construct is intended to enhance T-cell expansion, persistence, and polyfunctionality while reducing exhaustion, thereby improving the efficacy of T-cell therapies against solid tumors such as melanoma.
- Other names
- CD3zeta:MyD88 fusion proteinCD3z:MyD88CD3ζ-MyD88
02
Targets
Myeloid differentiation primary response 88 (MyD88)–Interleukin-1 receptor-associated kinase (IRAK)–TNF receptor-associated factor 6 (TRAF6) signaling axisCD3 (T-cell surface glycoprotein CD3)
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