Drug intelligence / Profile preview

cefaclor + metronidazole + ibuprofen

Development stage
Unknown
Lead developer
Huashan Hospital
Modality
Small Molecules
Administration
Oral
01

Overview

antibiotic-Huashan Hospital refers to a specific post-operative medication regimen used in a clinical trial (NCT03141580) conducted by Huashan Hospital to evaluate the efficacy of LED photobiomodulation therapy following mandibular third molar extraction. Although labeled as 'Antibiotic' in the trial's intervention list, the regimen is a multi-drug combination consisting of **cefaclor** (a second-generation cephalosporin antibiotic), **metronidazole** (a nitroimidazole antimicrobial), and **ibuprofen** (a nonsteroidal anti-inflammatory drug). Cefaclor provides coverage against aerobic bacteria by inhibiting cell wall synthesis, metronidazole targets anaerobic pathogens by disrupting DNA, and ibuprofen is utilized to manage post-surgical pain and inflammation by inhibiting cyclooxygenase enzymes.

Other names
Antibiotic (Huashan Hospital regimen)antibiotic-Huashan Hospital
02

Targets

PBP (Penicillin-binding protein family)PGHS-1 (Prostaglandin G/H Synthase 1)Neuraminidase

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