cefazolin + cephalexin

This antibiotic regimen consists of a combination of cefazolin and cephalexin administered as prophylaxis to prevent postoperative infections following cardiac implantable electronic device (CIED) implantation. Developed and studied by National Cheng-Kung University Hospital in the ABxFREE trial, the protocol involves standard pre-procedural prophylaxis followed by a one-day intravenous course of cefazolin and a subsequent three-day oral course of cephalexin. Both agents are first-generation cephalosporins that inhibit bacterial cell wall synthesis by binding to penicillin-binding proteins (PBPs), providing coverage against common surgical site pathogens such as *Staphylococcus aureus*. The regimen is specifically designed to evaluate whether extended post-procedural prophylaxis reduces infection rates compared to standard pre-procedural dosing alone.

Other names

ABxFREE antibiotic regimenpost-procedural antibiotic prophylaxiscefazolin and cephalexin prophylaxis