cefazolin + ketorolac + pantoprazole + paracetamol

This standardized perioperative medication regimen is utilized by Hospital da Luz, Portugal, as a baseline treatment for patients undergoing orthopedic surgery with neuraxial anesthesia. The combination therapy consists of four distinct pharmaceutical agents: cefazolin, a first-generation cephalosporin antibiotic used for surgical site infection prophylaxis; ketorolac, a potent non-steroidal anti-inflammatory drug (NSAID) for acute pain management; pantoprazole, a proton pump inhibitor (PPI) administered to prevent stress-induced gastric ulcers and reduce acid secretion; and paracetamol, a non-opioid analgesic and antipyretic. In the context of clinical research (NCT04441411), this regimen is administered to all study participants to ensure a consistent baseline of care while evaluating the comparative effects of midazolam versus propofol sedation on core temperature variations.

Other names

Standard medication regimen (Hospital da Luz)Standard treatment (NCT04441411)