Drug intelligence / Profile preview

cefixime + moxifloxacin

Development stage
Preclinical
Lead developer
Bayer
Modality
Small Molecules
Administration
Oral
01

Overview

Cefixime + moxifloxacin is a fixed-dose combination antibiotic therapy developed by Cosmas Pharmaceuticals. This combination pairs cefixime, a third-generation cephalosporin, with moxifloxacin, a fourth-generation fluoroquinolone, to provide a broad spectrum of antibacterial activity. Cefixime works by inhibiting bacterial cell wall synthesis through binding to penicillin-binding proteins (PBPs), which leads to cell lysis. Moxifloxacin acts by inhibiting DNA gyrase (topoisomerase II) and topoisomerase IV, enzymes essential for bacterial DNA replication, transcription, repair, and recombination. The product is specifically formulated as a sustained-release (SR) oral dosage form, typically containing 400mg of each component, intended for the treatment of various bacterial infections.

Other names
cefixime + moxifloxacin (SR)
02

Targets

PBP (Penicillin-binding protein family)DNA gyraseTopo IV (Bacterial Topoisomerase IV)

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