cefoxitin + tobramycin

Cefoxitin + tobramycin is an antibiotic combination used primarily for treating mixed aerobic/anaerobic infections. Cefoxitin is a semi-synthetic, broad-spectrum cephalosporin antibiotic derived from cephamycin C, while tobramycin is an aminoglycoside antibiotic. This combination is particularly effective for intra-abdominal and female pelvic infections. Studies have shown that when tobramycin therapy is discontinued if no cefoxitin-resistant pathogens are present, the duration of aminoglycoside therapy is significantly shorter compared to clindamycin plus tobramycin regimens (4.1 days vs 7.0 days), potentially reducing nephrotoxicity risks.