ceftolozane + tazobactam

**Ceftolozane + tazobactam** is an intravenously administered fixed-dose antibacterial combination marketed as **Zerbaxa**. It combines ceftolozane, an antipseudomonal cephalosporin that binds bacterial penicillin-binding proteins and inhibits peptidoglycan cell-wall synthesis, with tazobactam, an irreversible beta-lactamase inhibitor that protects ceftolozane from susceptible beta-lactamases. The product is approved for complicated intra-abdominal infection when used with metronidazole, complicated urinary tract infection including pyelonephritis, and hospital-acquired or ventilator-associated bacterial pneumonia caused by susceptible pathogens. ([merck.com](https://www.merck.com/product/usa/pi_circulars/z/zerbaxa/zerbaxa_pi.pdf))

Brand names

Zerbaxa

Other names

C/Tceftolozane + tazobactamceftolozane and tazobactamceftolozane-tazobactamceftolozane/tazobactam