Drug intelligence / Profile preview

ceftriaxone + imipenem

Development stage
Unknown
Lead developer
Roche
Modality
Small Molecules
Administration
Intravenous, Intramuscular
01

Overview

This is a combination of two separate antibiotics: ceftriaxone (a third-generation cephalosporin) and imipenem (a carbapenem, typically administered with cilastatin). Both are beta-lactam antibiotics that work by inhibiting bacterial cell wall synthesis. Ceftriaxone binds to carboxypeptidases, endopeptidases, and transpeptidases in the bacterial cytoplasmic membrane, while imipenem binds to penicillin-binding proteins (PBPs). This combination would provide broad-spectrum coverage against many types of bacteria, though they are not typically used together as standard therapy due to overlapping spectrums of activity.

02

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