ceftriaxone + metronidazole

Ceftriaxone + metronidazole is a combination of two antibiotics frequently used together for the empirical treatment of intra-abdominal infections, surgical site infection prophylaxis (notably in appendicitis), and other mixed aerobic-anaerobic bacterial infections. Ceftriaxone is a third-generation cephalosporin that inhibits bacterial cell wall synthesis by binding to penicillin-binding proteins, leading to cell lysis and death. It is effective against many Gram-negative and some Gram-positive bacteria. Metronidazole is an antibiotic and antiprotozoal agent that targets anaerobic bacteria and certain protozoa by generating free radicals that damage DNA, resulting in cell death. The combination provides broad-spectrum coverage against both aerobic (especially Gram-negative) and anaerobic pathogens, making it suitable for polymicrobial infections such as intra-abdominal sepsis or complicated appendicitis[2][4][3].

Brand names

RocephinFlagyl

Other names

ceftriaxonemetronidazole