Drug intelligence / Profile preview

ceftriaxone + metronidazole + rifampin + moxifloxacin + placebo

Development stage
Preclinical
Lead developer
Sanofi
Modality
Small Molecules
Administration
Intravenous, Oral, Intramuscular
01

Overview

This appears to be an experimental combination therapy that includes four active antibiotics (ceftriaxone, metronidazole, rifampin, and moxifloxacin) plus placebo. Ceftriaxone is a third-generation cephalosporin antibiotic with broad-spectrum activity against gram-negative bacteria. Metronidazole is an antibiotic effective against anaerobic bacteria. Rifampin is an antibiotic that inhibits bacterial RNA polymerase. Moxifloxacin is a fluoroquinolone antibiotic that disrupts bacterial DNA replication. The inclusion of placebo suggests this may be part of a clinical trial design where some components are being tested against others.

02

Targets

RNAP (Bacterial dna-dependent RNA polymerase)DNADNA gyrasePBP (Penicillin-binding protein family)Topo IV (Bacterial Topoisomerase IV)NeuraminidaseBacterial DNA topoisomerase

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