Drug intelligence / Profile preview

cefuroxime + dextrose

Development stage
Unknown
Lead developer
B. Braun
Modality
Small Molecules
Administration
Intravenous, Parenteral
01

Overview

Cefuroxime + dextrose is a sterile, nonpyrogenic, single-use injectable combination drug product consisting of the second-generation cephalosporin antibacterial agent cefuroxime sodium and dextrose injection as a diluent. Developed and manufactured by B. Braun Medical Inc., this formulation is typically provided in the DUPLEX® dual-chamber container, which allows for the storage of the drug and diluent separately until administration. Cefuroxime exerts its bactericidal activity by binding to and inhibiting penicillin-binding proteins (PBPs), which are essential for bacterial cell wall synthesis, leading to cell wall disruption and death. The dextrose component is included to achieve iso-osmolality for intravenous use. It is indicated for the treatment of various infections caused by susceptible bacteria, including lower respiratory tract infections, urinary tract infections, skin infections, septicemia, meningitis, and bone and joint infections, as well as for perioperative prophylaxis.

Other names
Cefuroxime for Injection and Dextrose InjectionCefuroxime Sodium and Dextrose InjectionCefuroxime in Dextrose Injection
02

Targets

PBP1A (Penicillin-binding protein 1A)PBP1B (Penicillin-binding protein 1B)

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