Drug intelligence / Profile preview

celecoxib + docetaxel + irinotecan

Development stage
Unknown
Lead developer
Pfizer
Modality
Small Molecules
Administration
Oral, Intravenous
01

Overview

This combination involves **celecoxib**, a selective cyclooxygenase-2 (COX-2) inhibitor; **docetaxel**, a taxane chemotherapy drug; and **irinotecan**, a topoisomerase I inhibitor. The combination was studied for treating advanced solid tumors but was not recommended due to its side effect profile and lack of enhanced efficacy[1][3].

02

Targets

TOP1 (DNA Topoisomerase I)PTGS2 (Prostaglandin-Endoperoxide Synthase 2)Microtubule

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