Drug intelligence / Profile preview

celecoxib + isotretinoin + temozolomide

Development stage: Unknown
Lead developer: Pfizer
Modality: Small Molecules
Administration: Oral

Overview

A combination of three drugs studied as a potential treatment for glioblastoma. Temozolomide is an alkylating agent that works by stopping cancer cells from making DNA. Celecoxib is a COX-2 inhibitor that may have anti-angiogenic properties. Isotretinoin is a retinoid that may affect cell differentiation. This combination was investigated in a factorial design phase I/II clinical trial, though results indicated that adding isotretinoin to dose-dense temozolomide may be detrimental to patient outcomes.

Targets

RARA (Retinoic acid receptor alpha)RXRA (Retinoid X receptor alpha)PTGS2 (Prostaglandin-Endoperoxide Synthase 2)DNA

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