celecoxib + lidocaine

Celecoxib + lidocaine is a combination of two active pharmaceutical ingredients used for pain management. Celecoxib is a selective cyclooxygenase-2 (COX-2) inhibitor classified as a non-steroidal anti-inflammatory drug (NSAID), which reduces inflammation and pain by inhibiting the synthesis of prostaglandins in inflamed tissues. Lidocaine is a local anesthetic that works by blocking voltage-gated sodium channels, thereby preventing nerve impulse conduction and providing localized numbness or analgesia. This combination may be formulated for topical or other routes to provide both anti-inflammatory and local anesthetic effects, particularly in musculoskeletal or neuropathic pain settings[4][6]. There are no widely approved fixed-dose combination products containing only celecoxib and lidocaine, but such combinations have been studied in clinical trials for acute pain control[3].