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celecoxib + temozolomide + thalidomide

Development stage: Unknown
Lead developer: Pfizer
Modality: Small Molecules
Administration: Oral

Overview

A combination therapy consisting of celecoxib (a COX-2 inhibitor), temozolomide (an alkylating agent), and thalidomide (an immunomodulatory and anti-angiogenic agent). While celecoxib + temozolomide has been studied in clinical trials for melanoma and glioblastoma, and thalidomide is used for multiple myeloma and other conditions, the specific triple combination of all three drugs does not appear to have established clinical evidence in the provided information.

Targets

CRBN (Cereblon)PTGS2 (Prostaglandin-Endoperoxide Synthase 2)DNA

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