cephalexin + saline + probenecid

This combination refers to a specific treatment arm in a clinical trial conducted by Kelowna General Hospital for the treatment of uncomplicated cellulitis. The regimen consists of oral cephalexin (a first-generation cephalosporin antibiotic), intravenous saline (acting as a placebo for cefazolin), and oral probenecid (or its placebo). Cephalexin works by inhibiting bacterial cell wall synthesis through binding to penicillin-binding proteins. Probenecid is typically used to increase the plasma concentration and prolong the half-life of beta-lactam antibiotics by inhibiting their renal tubular secretion. The trial aimed to determine if oral cephalexin is non-inferior to the standard intravenous cefazolin plus probenecid regimen.