cephalosporin + metronidazole

Cephalosporin + metronidazole is an antibiotic combination regimen evaluated by Dongtan Sacred Heart Hospital for the treatment of acute uncomplicated right-sided diverticulitis. This combination therapy typically involves a third-generation cephalosporin, which provides broad-spectrum coverage against Gram-negative and Gram-positive aerobic bacteria by inhibiting bacterial cell wall synthesis through binding to penicillin-binding proteins (PBPs). Metronidazole is added to provide specific activity against anaerobic bacteria by disrupting DNA synthesis. In the clinical trial context (NCT02840110), the regimen was administered intravenously followed by an oral course to determine if antibiotic treatment is superior to supportive care (bowel rest) in patients with right-sided colonic diverticulitis.

Other names

3rd generation cephalosporin + metronidazolecephalosporin-Dongtan Sacred Heart Hospital-diverticulitis (right-sided)