certepetide + FOLFOX

Certepetide + FOLFOX is a **combination drug regimen** consisting of certepetide (a cyclic peptide designed to target and enhance uptake of co-administered anti-cancer drugs into solid tumors by binding to alpha-v integrins and activating an uptake pathway through neuropilin-1) and **FOLFOX**, a chemotherapy regimen comprised of folinic acid (leucovorin), fluorouracil (5-FU), and oxaliplatin, used primarily in the treatment of colorectal and other solid cancers[1][2][3][4][5][6]. Certepetide works by increasing drug delivery to tumors and modulating the tumor microenvironment (including effects on immunosuppressive and cytotoxic T cells), while FOLFOX acts as a standard cytotoxic chemotherapy targeting rapidly dividing cells. The combination is under investigation for improving outcomes in solid tumors (notably pancreatic and colorectal cancers).

Other names

certepetide + FOLFOX