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cetuximab + cisplatin + pemetrexed

Development stage: Unknown
Lead developer: Eli Lilly
Modality: Monoclonal Antibodies → Antibody-Based Therapeutics, Small Molecules
Administration: Intravenous

Overview

Cetuximab + cisplatin + pemetrexed is a combination therapy that has been investigated in clinical trials for the treatment of recurrent or metastatic squamous cell carcinoma of the head and neck (SCCHN), non-small cell lung cancer (NSCLC), and malignant pleural mesothelioma. This regimen combines a monoclonal antibody targeting EGFR (cetuximab) with a platinum-based chemotherapy agent (cisplatin) and an antifolate antineoplastic agent (pemetrexed).

Other names: pemetrexed + cisplatin + cetuximab

Targets

GART (GAR transformylase)TS (Thymidylate synthase)DNAEGFR T790M (Epidermal growth factor receptor T790M mutant)DHFR (Dihydrofolate reductase)

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