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cetuximab + FOLFIRI + FOLFOX
- Development stage
- Unknown
- Lead developer
- Pfizer
- Modality
- Monoclonal Antibodies → Antibody-Based Therapeutics, Small Molecules
- Administration
- Intravenous
01
Overview
A combination therapy regimen used in the treatment of colorectal cancer. This regimen combines cetuximab, a monoclonal antibody targeting EGFR, with two chemotherapy combinations: FOLFIRI (folinic acid, fluorouracil, and irinotecan) and FOLFOX (folinic acid, fluorouracil, and oxaliplatin). The combination may be used sequentially or in alternating cycles to maximize efficacy while managing toxicity profiles.
- Other names
- Cetuximab plus FOLFOX6 or FOLFIRICECOG regimen
02
Targets
TOP1 (DNA Topoisomerase I)EGFR T790M (Epidermal growth factor receptor T790M mutant)DNATS (Thymidylate synthase)
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