Drug intelligence / Profile preview

cetuximab + gemcitabine

Development stage
Phase 2
Lead developer
Eli Lilly
Modality
Monoclonal Antibodies → Antibody-Based Therapeutics, Small Molecules
Administration
Intravenous
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Overview

Cetuximab + gemcitabine is a combination therapy used in cancer treatment. Cetuximab is a monoclonal antibody that targets the epidermal growth factor receptor (EGFR), while gemcitabine is a nucleoside analog that works as an antimetabolite. This combination has been studied in clinical trials for various cancer types, including non-small-cell lung cancer and cholangiocarcinoma. The combination has shown promising efficacy with an acceptable toxicity profile.

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Targets

DNA polymerase familyEGFR (Epidermal growth factor receptor)RNR (Ribonucleotide reductase)

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