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cetuximab + ixabepilone
- Development stage
- Unknown
- Lead developer
- Eli Lilly
- Modality
- Monoclonal Antibodies → Antibody-Based Therapeutics, Small Molecules
- Administration
- Intravenous
01
Overview
Cetuximab + ixabepilone is a combination therapy that pairs an EGFR-targeted monoclonal antibody (cetuximab) with a microtubule stabilizer (ixabepilone). This combination has been investigated primarily for triple-negative breast cancer (TNBC) and pancreatic cancer. Cetuximab targets the epidermal growth factor receptor (EGFR), which plays key roles in metastasis, tumorigenesis, cell proliferation, and drug resistance. Ixabepilone is a microtubule-stabilizing agent that disrupts cell division. The combination aims to simultaneously target multiple pathways involved in cancer progression, with cetuximab specifically shown to reduce cancer stem cell (CSC) populations in TNBC tumors.
- Brand names
- IxempraErbitux
- Other names
- epothilone B analog (for ixabepilone)
02
Targets
MicrotubuleEGFR (Epidermal growth factor receptor)
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