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ChAdOx1 NP+M1
- Development stage
- Phase 1
- Lead developer
- University of Oxford
- Modality
- Viral Vector Vaccines → Recombinant Vaccines → Prophylactic Vaccines → Vaccines & Immunotherapeutics
- Administration
- Intramuscular
01
Overview
ChAdOx1 NP+M1 is a replication-deficient chimpanzee adenovirus-vectored vaccine expressing the conserved influenza antigens nucleoprotein (NP) and matrix protein 1 (M1). It was developed by the Jenner Institute at the University of Oxford as a potential universal influenza vaccine. The vaccine uses the ChAdOx1 vector, which is derived from a chimpanzee adenovirus (ChAd) serotype Y25 engineered to avoid replication. This approach overcomes the limitation of pre-existing immunity to human adenoviruses. ChAdOx1 NP+M1 is designed to induce strong cellular immune responses, particularly T-cell responses, which could provide broad protection against different influenza strains.
- Other names
- ChAdOx1-NP + M1-University of Oxford-influenzaChAdOx1-NP+M1 influenza vaccine
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