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Chang'an II Recipe
- Development stage
- Phase 4
- Administration
- Oral
01
Overview
Chang'an II Recipe is a traditional Chinese medicine (TCM) herbal prescription derived from the classical formula Tong-Xie-Yao-Fang. It is primarily used for the treatment of irritable bowel syndrome (IBS), particularly in cases associated with liver-qi stagnation and spleen deficiency syndromes. Preclinical studies indicate that it exerts anti-inflammatory, immunomodulatory, and anti-anxiety effects. In animal models of post-inflammation IBS (PI-IBS), it has been shown to repair intestinal mucosal barrier damage by modulating immune cell ratios (CD4+/CD8+), reducing pro-inflammatory cytokines such as IL-1β, increasing anti-inflammatory cytokines like IL-4, and improving behavioral symptoms related to anxiety and depression. The mechanism may also involve inhibition of MLCK-mediated pathways contributing to intestinal barrier protection[1][3][2].
- Brand names
- Chang'an II
- Other names
- Chang'an IIChang’an II herbal prescriptionChang’an II formula
02
Targets
IL-4 (Interleukin 4)MLCK (Myosin light chain kinase)IL1B (Interleukin-1 beta)
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