Drug intelligence / Profile preview

Changweishu + meropenem + noradrenaline

Development stage
Unknown
Lead developer
Pfizer
Modality
Orthosteric Ligands → Classical Binding Small Molecules → Small Molecules
Administration
Oral, Intravenous
01

Overview

The combination "Changweishu + meropenem + noradrenaline" appears to be a treatment regimen that combines a traditional Chinese medicine (Changweishu) with two conventional Western medications (meropenem and noradrenaline). **Changweishu** is a traditional Chinese medicine formulation that appears to be used for treating gastrointestinal dysfunction, particularly in patients with sepsis. It works by "purging fu-organs to eliminate heat". According to the search results, Changweishu is available in capsule form and has been studied for its effects on tumor-related diarrhea and constipation. **Meropenem** is a carbapenem antibiotic used to treat a variety of bacterial infections. It works by inhibiting cell wall synthesis in bacteria. While not explicitly mentioned in the search results, meropenem is commonly used in the treatment of sepsis, which aligns with the context in which Changweishu is mentioned. **Noradrenaline** (also known as norepinephrine) is a vasopressor medication used to treat hypotension (low blood pressure), particularly in shock states including septic shock. It works by constricting blood vessels to increase blood pressure. Like meropenem, noradrenaline is not explicitly mentioned in the search results but is commonly used in sepsis management. The combination of these three agents suggests a comprehensive approach to treating sepsis with associated gastrointestinal dysfunction, where: - Changweishu addresses the gastrointestinal symptoms - Meropenem targets the underlying infection - Noradrenaline manages the hemodynamic instability (low blood pressure) often seen in sepsis

Other names
Changweishu + meropenem + norepinephrine
02

Targets

PBP (Penicillin-binding protein family)AR (Adrenergic receptors)

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