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charlotte's web

Development stage: Preclinical
Lead developer: Charlotte's Web
Modality: Metabolically Activated Prodrugs → Prodrugs/Conditional Activator Small Molecules → Small Molecules, Classical Binding Small Molecules → Small Molecules
Administration: Oral, Sublingual, Topical

Overview

Charlotte's Web is a full-spectrum hemp extract containing cannabidiol (CBD) and other cannabinoids with less than 0.3% THC. It was originally developed by the Stanley Brothers in 2012 for Charlotte Figi, a girl with Dravet syndrome, whose seizures were significantly reduced by using this product. The extract is derived from a specific strain of hemp that maintains a high CBD to THC ratio (approximately 30:1). Charlotte's Web products are extracted using either carbon dioxide (CO2) or isopropyl alcohol methods to preserve various beneficial compounds including cannabinoids, terpenes, and flavonoids.

Brand names: Charlotte's Web

Targets

HTR1A (Serotonin receptor 1A (5-hydroxytryptamine receptor 1A))Cyp (Cyclophilin family)

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