chemotherapy + platinum agent

Chemotherapy + platinum agent refers to a combination cancer treatment regimen that includes a platinum-based chemotherapeutic drug (such as cisplatin, carboplatin, or oxaliplatin) together with one or more other cytotoxic agents. Platinum agents are coordination complexes of platinum and act primarily by forming DNA crosslinks that inhibit DNA repair and synthesis, leading to apoptosis in rapidly dividing cells. These regimens are widely used for various solid tumors including lung, ovarian, testicular, colorectal, head and neck cancers among others. The specific non-platinum drugs combined with the platinum agent vary depending on the cancer type and clinical protocol[2][3][4][5][6]. Platinum agents are considered "alkylating-like" due to their mechanism but do not contain alkyl groups[3]. Commonly used combinations include cisplatin or carboplatin with drugs such as paclitaxel, etoposide, pemetrexed or gemcitabine.

Other names

platinum-based chemotherapyplatin-based combination therapy