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Chinese Academy of Medical Sciences & Peking Union Medical College STAT3 compound L20
- Development stage
- Preclinical
- Lead developer
- Chinese Academy of Medical Sciences Peking Union Medical College
01
Overview
Chinese Academy of Medical Sciences & Peking Union Medical College STAT3 compound L20: sourced facts only. name: "Mechanistic investigations confirmed that L20 directly binds to STAT3 protein (KD = 6.16 μM), specifically interacting with its SH2 domain." [PMID:41564506]; target: "Mechanistic investigations confirmed that L20 directly binds to STAT3 protein (KD = 6.16 μM), specifically interacting with its SH2 domain." [PMID:41564506]; developer: "State Key Laboratory of Digestive Health, Beijing Key Laboratory of Active Substances Discovery and Druggability Evaluation, Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100050, China." [PMID:41564506]; stage: "Notably, in a murine MC38 subcutaneous xenograft model, L20 administration (20 mg/kg, i.p.) significantly suppressed tumor growth, achieving a tumor growth inhibition rate of 59.8 %." [PMID:41564506]
02
Targets
STAT3 (Signal Transducer and Activator of Transcription 3)
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