chitosan + capsaicin

**Chitosan + capsaicin** refers to a combination where capsaicin (an agonist of the TRPV1 receptor with thermogenic, analgesic, and epithelial permeabilizing properties) is encapsulated or formulated together with chitosan (a cationic biopolymer derived from chitin) as a microsphere or nanoformulation. The goal is to improve the delivery, reduce the gastric irritancy, sustain the release, and mitigate the cytotoxicity of capsaicin through mucoadhesion, protection, and controlled release provided by chitosan. These formulations are studied primarily as drug or supplement delivery systems for conditions such as obesity, for improved intestinal absorption of co-delivered drugs, and for their potential to modulate epithelial permeability[1][2][3]. The combination exploits chitosan's biocompatibility, mucoadhesive, and permeation-enhancing properties, together with capsaicin's known pharmacological effects. It can be delivered orally (e.g. as enteric-coated tablets) or via mucosal routes (e.g. nanoparticles/nanocapsules).

Other names

capsaicin-chitosan microspherescapsaicin-loaded chitosan nanocapsules