chloramphenicol + tetracycline + zinc oxide + eugenol

This drug is a fixed-dose combination dental paste consisting of chloramphenicol, tetracycline, zinc oxide, and eugenol, primarily indicated for the treatment and prevention of alveolar osteitis (dry socket). Chloramphenicol and tetracycline provide synergistic broad-spectrum antibacterial activity by inhibiting protein synthesis at the 50S and 30S ribosomal subunits, respectively, targeting pathogens common in post-extraction infections. Zinc oxide acts as a mild antiseptic and astringent base that facilitates the formation of a protective physical barrier over the exposed alveolar bone. Eugenol, a clove-derived phenolic compound, provides local analgesic and sedative effects, likely through the inhibition of prostaglandin synthesis and modulation of nerve conduction, effectively managing the acute pain characteristic of dry socket.

Brand names

Alveopen

Other names

chloramphenicol/tetracycline/zinc oxide/eugenolAlveopen dental paste