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chlorazolamide-Zn(II) complex
- Development stage
- Preclinical
- Modality
- Small Molecules
- Administration
- Ophthalmic, Topical
01
Overview
Chlorazolamide-Zn(II) complex is a metal-based coordination compound developed for the treatment of glaucoma and ocular hypertension. It is formed by the interaction of the sulfonamide chlorazolamide (5-(2-chlorophenyl)-1,3,4-thiadiazole-2-sulfonamide) with zinc(II) ions. While the parent sulfonamide exhibits poor topical penetration and weak intraocular pressure (IOP) lowering effects, the zinc complex significantly enhances pharmacological activity and bioavailability in ocular tissues. The drug acts as a potent inhibitor of carbonic anhydrase (CA) isozymes, particularly CA II, which is essential for the secretion of aqueous humor. By inhibiting these enzymes in the ocular fluids and tissues, the complex effectively reduces IOP, as demonstrated in experimental animal models.
- Other names
- zinc(II) chlorazolamide5-(2-chlorophenyl)-1,3,4-thiadiazole-2-sulfonamide zinc(II) complex
02
Targets
CA (Carbonic anhydrase)
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