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chlorhexidine + alcohol
- Development stage
- Phase 4
- Lead developer
- AkzoNobel
- Modality
- Small Molecules
- Administration
- Topical
01
Overview
Chlorhexidine + alcohol is a topical antiseptic combination used primarily for skin disinfection prior to surgical procedures or injections. The formulation typically contains chlorhexidine gluconate (an antiseptic biguanide compound) and isopropyl alcohol. Chlorhexidine acts as a broad-spectrum antimicrobial agent by binding to negatively charged bacterial cell walls and disrupting membrane integrity at higher concentrations. Alcohol provides rapid bactericidal action through protein denaturation and membrane disruption. Together, the combination offers both immediate and persistent antimicrobial activity against a wide range of bacteria (gram-positive and gram-negative), yeasts, and some viruses[1][3][6][8]. This product is widely used in healthcare settings for preoperative skin preparation.
- Brand names
- ChloraPrep One-StepDyna-HexHibiclensBetaseptBiopatchScrub Care ExidineSpectrum-4Spectrum4Spectrum 4
- Other names
- chlorhexidine-alcohol solutionchlorhexidine gluconate and isopropyl alcohol solution
02
Targets
Bacterial cell membrane phospholipids and anionic surface components
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