chlorhexidine + ammonium chloride

**Chlorhexidine + ammonium chloride** is a combination of two antiseptic agents: *chlorhexidine*, a broad-spectrum antimicrobial cationic biguanide, and *ammonium chloride*, which belongs to the quaternary ammonium compound family. Used primarily as a topical disinfectant or antiseptic, such combinations are designed to provide enhanced antibacterial and antifungal coverage. Chlorhexidine acts by disrupting microbial cell membranes and precipitating cell contents, while ammonium chloride disrupts microbial membranes and proteins through its surfactant properties. Together, these mechanisms can result in additive or synergistic effects against a broad spectrum of bacteria, including Gram-positive and Gram-negative species, as well as some fungi. This combination is typically studied for potential additive or synergistic activity in formulations for skin disinfection, wound care, or potentially veterinary antiseptic use[1]. The product is formulated for topical administration and is not for systemic use.

Brand names

PerioGard

Other names

0.3% chlorhexidine and 3% AmCl toothpasteColgate Chlorhexidine Toothpaste