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**chloroprocaine + morphine** is a sequential epidural co-administration regimen evaluated by Northwestern University in a completed randomized study of women undergoing postpartum tubal ligation. The regimen used epidural 3% chloroprocaine for short-acting surgical anesthesia followed by preservative-free epidural morphine at skin incision for postoperative analgesia; saline was administered as a placebo before chloroprocaine in the SCM study arm. Chloroprocaine is an ester local anesthetic that inhibits neuronal impulse generation and conduction, while morphine is a full opioid agonist with relative selectivity for the mu-opioid receptor. ([clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00487084))
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