chlorphenamine + dexamethasone

**Chlorphenamine + dexamethasone** is a combination drug comprising a first-generation antihistamine (chlorphenamine, also known as chlorpheniramine) and a synthetic glucocorticoid corticosteroid (dexamethasone)[3][8][7]. Chlorphenamine acts as a competitive antagonist at the histamine H1 receptor, thereby reducing allergic symptoms such as itching, sneezing, and rash[3][6]. Dexamethasone binds to the glucocorticoid receptor, inhibiting inflammatory mediators and transcription factors (such as NF-κB and phospholipase A2), and modulating gene expression to produce anti-inflammatory and immunosuppressive effects[1][3][5]. The combination is used for anti-allergic and anti-inflammatory therapy in dermatology and allergy, and in veterinary medicine for symptomatic relief and recovery, particularly in allergy and joint/muscle inflammation[3][8]. The drugs provide synergistic effects, allowing reduced doses of corticosteroids and antihistamines, increasing clinical efficacy and potentially reducing adverse effects[5].

Brand names

Dexalergin

Other names

chlorpheniramine + dexamethasonechlorphenamine maleate + dexamethasonechlorpheniramine maleate + dexamethasone