chlorpheniramine + dextromethorphan + phenylephrine (Alliant Pharmaceuticals)

Rondec DM is an oral combination medication containing chlorpheniramine maleate, dextromethorphan hydrobromide, and phenylephrine hydrochloride. It is indicated for the symptomatic relief of cough, nasal congestion, and allergic symptoms associated with the common cold, influenza, hay fever, or other upper respiratory allergies such as sinusitis and bronchitis. Chlorpheniramine is a first-generation antihistamine that competes with histamine for H1-receptor sites on effector cells. Dextromethorphan is an antitussive agent that acts centrally on the cough center in the medulla, primarily through sigma-1 receptor agonism and NMDA receptor antagonism. Phenylephrine is a sympathomimetic amine that acts as a decongestant by stimulating alpha-1 adrenergic receptors, leading to vasoconstriction in the nasal mucosa and reducing sinus pressure. The drug was developed and manufactured by Alliant Pharmaceuticals and is typically available in syrup or drop formulations.

Brand names

Rondec DM