chlorpheniramine + phenylephrine

Chlorpheniramine + phenylephrine is an oral combination drug used to relieve symptoms associated with the common cold, seasonal allergies, hay fever, or sinus inflammation. It combines two active ingredients: **Chlorpheniramine**, an antihistamine that blocks histamine H1 receptors to reduce symptoms like sneezing, itching, watery eyes, and runny nose; **Phenylephrine**, a sympathomimetic decongestant that acts as an alpha‑adrenergic receptor agonist to constrict blood vessels in the nasal passages, thereby reducing nasal congestion. This combination provides short-term relief of multiple upper respiratory symptoms such as runny or stuffy nose, sneezing, itchy/watery eyes or throat, sinus congestion/pressure. It is available over-the-counter in various formulations including tablets and liquids[1][2][4][6].

Brand names

Actifed Cold and AllergyAllerest PEChlorTan DCold and Allergy ReliefEd A-HistMaxichlor PEHNoHistPhenagilSudafed PE Sinus and Allergy

Other names

chlorpheniramine and phenylephrinechlorpheniramine maleate + phenylephrine