Drug intelligence / Profile preview

chlorpromazine + haloperidol + risperidone + thioridazine + trifluoperazine

Development stage
Unknown
Lead developer
Janssen Pharmaceutica
Modality
Small Molecules
Administration
Oral, Intramuscular
01

Overview

This is a combination of five antipsychotic medications, including four first-generation (typical) antipsychotics (chlorpromazine, haloperidol, thioridazine, trifluoperazine) and one second-generation (atypical) antipsychotic (risperidone). The combination includes drugs with different receptor binding profiles and side effect patterns. First-generation antipsychotics primarily block dopamine D2 receptors in the brain, while risperidone also antagonizes 5-HT2A receptors. This combination would likely be used for treatment-resistant schizophrenia or acute psychosis, though specific evidence for this particular five-drug combination is not well-documented in clinical literature.

02

Targets

HTR2A (Serotonin receptor 5-HT2A)HRH1 (Histamine H1 Receptor)ADRA1A (α1A)DRD2 (Dopamine D2 Receptor)mAChR (Muscarinic acetylcholine receptors)

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