chlorpromazine + promethazine + pethidine

This drug is a fixed-dose combination of three agents—chlorpromazine, promethazine, and pethidine—commonly known in China as "冬眠合剂" (Hibernation Mixture). It is used primarily for deep sedation and as an adjunct in anesthesia, especially in neurosurgical or critical care settings. The combination leverages the pharmacological actions of each component: - **Chlorpromazine** is a phenothiazine antipsychotic that acts mainly as a dopamine receptor antagonist with additional antihistaminic and anticholinergic effects. It provides strong sedative and antiemetic properties. - **Promethazine** is a first-generation antihistamine (H1 receptor antagonist) with significant sedative, antiemetic, and anticholinergic effects. - **Pethidine** (also known as meperidine) is an opioid analgesic acting primarily on the mu-opioid receptor to provide pain relief. The mixture produces synergistic sedation, analgesia, muscle relaxation, hypothermia induction (for therapeutic hypothermia), reduction of cerebral metabolic rate/oxygen consumption, protection against brain edema after trauma or surgery, and prevention of secondary brain injury. This allows for lower doses of each drug than if used alone[1][3][4][6].

Brand names

冬眠合剂

Other names

冬眠I号冬眠合剂一号