cholecalciferol + curcumin

Cholecalciferol + curcumin is a combination of two bioactive compounds commonly used as dietary supplements. Cholecalciferol (vitamin D3) is a secosteroid hormone involved in calcium and phosphate homeostasis and bone metabolism, acting primarily through the vitamin D receptor to regulate gene expression. Curcumin is a polyphenolic compound derived from turmeric (Curcuma longa), known for its anti-inflammatory, antioxidant, immunomodulatory, and potential anticancer properties. The combination has been investigated for synergistic effects in modulating immune responses and inflammation. Clinical studies suggest that this combination may improve disease activity scores and inflammatory cytokine profiles in conditions such as systemic lupus erythematosus (SLE), chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL/SLL), rheumatoid arthritis models, and early-stage COVID-19[1][2][4][5][8]. The mechanisms involve modulation of inflammatory cytokines (e.g., IL-6 reduction), enhancement of anti-inflammatory mediators (e.g., TGF-β increase), suppression of cellular infiltration into tissues, inhibition of matrix metalloproteinases, and possible direct effects on malignant cell growth.

Other names

vitamin D3 + curcumincurcumin + vitamin D3