Drug intelligence / Profile preview

cholecalciferol + vitamin K

Development stage
Unknown
Lead developer
Metagenics
Modality
Small Molecules
Administration
Oral
01

Overview

Vitamin D3 + Vitamin K-Nupathways is a high-potency dietary supplement combination featuring cholecalciferol (Vitamin D3) and Vitamin K, developed by Metagenics in partnership with Nupathways. Vitamin D3 functions as a steroid hormone precursor that binds to the Vitamin D receptor (VDR), promoting intestinal calcium absorption and maintaining serum calcium and phosphate concentrations for bone mineralization. Vitamin K, typically provided in its K1 and K2 (menaquinone-7) forms, acts as an essential cofactor for the enzyme gamma-glutamyl carboxylase, which activates proteins like osteocalcin for bone formation and matrix Gla protein (MGP) to prevent vascular calcification. This combination is designed to support bone density, cardiovascular health, and immune system regulation by ensuring proper calcium utilization within the body.

Brand names
Vitamin D3 5,000 + KVitamin D3 + Vitamin K-Nupathways
Other names
Vitamin D3 + KVitamin D3 5,000 + K by Metagenics
02

Targets

VDR (Vitamin D receptor)GGCX (Vitamin K-dependent gamma-glutamyl carboxylase)

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