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chondroitin sulfate + glucosamine sulfate
- Development stage
- Unknown
- Lead developer
- Azidus Brasil
- Modality
- Implantable Hydrogels → Hydrogel Systems → Drug Delivery Systems, Small Molecules, Non-biodegradable Polymers → Polymer-based Nanoparticles → Nanoparticles → Drug Delivery Systems, Biodegradable Polymers → Polymer-based Nanoparticles → Nanoparticles → Drug Delivery Systems, Injectable Hydrogels → Hydrogel Systems → Drug Delivery Systems
- Administration
- Oral
01
Overview
Chondroitin sulfate + glucosamine sulfate is a combination therapy used for the treatment of osteoarthritis, particularly of the knee. Glucosamine sulfate is an amino sugar that serves as a building block for glycosaminoglycans and proteoglycans in articular cartilage. Chondroitin sulfate is a complex polysaccharide that provides resistance to compression and inhibits enzymes that degrade cartilage, such as matrix metalloproteinases. Together, they aim to reduce joint pain, improve mobility, and potentially slow the progression of joint space narrowing. This specific formulation, manufactured by Geolab and sponsored by Azidus Brasil, was evaluated in a Phase 3 trial to demonstrate non-inferiority to the reference product Condroflex.
- Brand names
- Condroflex
- Other names
- glucosamine sulfate and chondroitin sulfate combination
02
Targets
NF-κBMMP12 (Macrophage Metalloelastase)IL1B (Interleukin-1 beta)
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