Drug intelligence / Profile preview

cilnidipine + telmisartan

Development stage
Unknown
Lead developer
Unilex Lifesciences
Modality
Small Molecules
Administration
Oral
01

Overview

Cilnifix T is a fixed-dose combination of cilnidipine and telmisartan, developed and marketed by Unilex Lifesciences for the treatment of hypertension. Cilnidipine is a dual L-type and N-type calcium channel blocker (CCB). Unlike traditional CCBs that only target L-type channels, cilnidipine's inhibition of N-type channels in sympathetic nerve endings suppresses norepinephrine release, which helps prevent reflex tachycardia and provides additional organ protection. Telmisartan is a potent, long-acting angiotensin II receptor blocker (ARB) that selectively binds to the AT1 receptor, inhibiting the vasoconstrictive and sodium-retaining effects of angiotensin II. This combination therapy is designed to provide comprehensive blood pressure control and cardiovascular risk reduction.

Brand names
Cilnifix T
Other names
Cilnidipine + Telmisartan
02

Targets

LTCC (Voltage-gated calcium channel (L-type))AGTR1 (Angiotensin II Type-1 receptor)CACNA1B (Voltage-dependent N-type calcium channel subunit alpha-1B)

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