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ciprofloxacin + metronidazole
- Development stage
- Unknown
- Lead developer
- MinaPharm
- Modality
- Small Molecules
- Administration
- Oral
01
Overview
Ciprofloxacin + metronidazole is a combination antibiotic regimen being investigated by Sunnybrook Health Sciences Centre in the PARFAIT (Perianal Abscess Recurrence and Fistula Formation: Antibiotics Following Incision and Drainage) trial. The regimen consists of ciprofloxacin, a fluoroquinolone that inhibits bacterial DNA gyrase and topoisomerase IV, and metronidazole, a nitroimidazole that causes DNA strand breakage in anaerobic bacteria. This combination provides broad-spectrum coverage against gram-positive, gram-negative, and anaerobic pathogens. It is being evaluated as a post-surgical treatment following the incision and drainage of perianal abscesses to reduce the incidence of perianal fistula formation and abscess recurrence.
- Brand names
- Flagyl
- Other names
- Antibiotic 2 arm (PARFAIT trial)
02
Targets
MAPK1 (Mitogen-activated protein kinase 1)Topo IV (Bacterial Topoisomerase IV)RAC1 (Rac family small GTPase 1)DNA gyrase
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