Drug intelligence / Profile preview

ciprofloxacin + valortim

Development stage
Unknown
Lead developer
Bayer
Modality
Monoclonal Antibodies → Antibody-Based Therapeutics, Small Molecules
Administration
Oral, Intravenous, Ophthalmic, Otic
01

Overview

Ciprofloxacin is a second-generation fluoroquinolone antibiotic used to treat a wide range of bacterial infections. It acts by inhibiting bacterial DNA gyrase and topoisomerase IV enzymes required for DNA replication and transcription. Ciprofloxacin is available in multiple formulations (oral tablets and liquid, intravenous injection, eye drops, ear drops) and is indicated for skin and soft tissue infections; bone and joint infections; complicated intra-abdominal infections (with metronidazole); respiratory tract infections including pneumonia; urinary tract infections; chronic bacterial prostatitis; anthrax exposure; plague; typhoid fever; infectious diarrhea; acute sinusitis among others[1][3][4][5][8]. Valortim is a monoclonal antibody developed as an immunotherapeutic agent targeting *Bacillus anthracis* protective antigen (PA), intended primarily for the prevention or treatment of inhalational anthrax. It works by binding to the PA component of anthrax toxin to neutralize its effects.

Brand names
CetraxalCiloxanCipro HCCiprodexOtiprioOtixalOtovel
Other names
Valortim and ciprofloxacinMDX-1303 and ciprofloxacinMDX1303 and ciprofloxacinMDX 1303 and ciprofloxacinAVP-21D9 and ciprofloxacinAVP21D9 and ciprofloxacinAVP 21D9 and ciprofloxacin
02

Targets

PA (Influenza polymerase acidic protein)DNA gyraseTopo IV (Bacterial Topoisomerase IV)

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