cis-[4,5-bis-(4-chlorophenyl)-2-(2-isopropoxy-4-methoxyphenyl)-4,5-dihydroimidazol-1-yl]-piperazin-1-yl-methanone

This compound is a synthetic small molecule with the formula C30H32Cl2N4O3 and a molecular weight of approximately 567.51 g/mol. It is structurally related to the class of compounds known as nutlins—cis-imidazoline derivatives that act as potent antagonists of the MDM2-p53 interaction. By inhibiting MDM2 (mouse double minute 2 homolog), these molecules stabilize and activate p53 tumor suppressor protein function in cells with wild-type TP53 gene status. The drug has been studied primarily as a research tool for probing p53 pathway biology and has not been approved for clinical use or advanced into late-stage clinical trials[1][7][8]. No approved indications or marketed products exist for this specific compound.

Other names

CIS-[4,5-BIS-(4-CHLOROPHENYL)-2-(2-ISOPROPOXY-4-METHOXYPHENYL)-4,5-DIHYD ROIMIDAZOL-1-YL]-PIPERAZIN-1-YL-METHANONE1-{[4,5-bis(4-chlorophenyl)-2-(2-isopropoxy-4-methoxyphenyl)-4,5-dihydroimidazol-1-yl]carbonyl}piperazine[(4S,5R)-4,5-bis(4-chlorophenyl)-2-(2-isopropoxy-4-methoxyphenyl)-4,5-dihydroimidazol-1-y](1-piperazinyl)methanonerel-((R,S))-bis(aryl)imidazoline piperazine derivative