cisapride + omeprazole

Cisapride + omeprazole is a combination of two pharmaceutical agents used in the management of gastroesophageal reflux disease (GERD) and related esophagitis. Cisapride is a prokinetic agent that acts as a serotonin 5-HT4 receptor agonist, enhancing acetylcholine release in the enteric nervous system to stimulate gastrointestinal motility and accelerate gastric emptying. Omeprazole is a proton pump inhibitor (PPI) that suppresses gastric acid secretion by irreversibly inhibiting the H+/K+ ATPase enzyme system at the secretory surface of gastric parietal cells. The combination has been studied for its potential to improve healing rates and reduce relapse in mild-to-moderate esophagitis, with evidence suggesting that maintenance therapy with cisapride after initial healing with both drugs can significantly reduce relapse rates compared to omeprazole monotherapy[3][6]. This combination does not have unique brand names or code names and is not widely marketed as a fixed-dose product.