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cisplatin + carboplatin + paclitaxel + docetaxel-Swami Rama Himalayan University
- Development stage
- Phase 3
- Lead developer
- Swami Rama Himalayan University
- Modality
- Small Molecules
- Administration
- Intravenous
01
Overview
This entry refers to a grouping of platinum-based (cisplatin, carboplatin) and taxane-based (paclitaxel, docetaxel) chemotherapy agents utilized in a clinical study conducted by Swami Rama Himalayan University. These agents are standard-of-care treatments for various solid tumors, including head and neck, breast, and prostate cancers. Cisplatin and carboplatin act as DNA alkylating-like agents that form intra-strand and inter-strand cross-links, inhibiting DNA replication and transcription. Paclitaxel and docetaxel are microtubule stabilizers that bind to the beta-subunit of tubulin, preventing microtubule depolymerization and leading to cell cycle arrest in the G2/M phase. The specific study mentioned evaluates chemotherapy-induced peripheral neuropathy (CIPN) associated with these agents, utilizing biomarkers such as NOX4 expression and vitamin levels to assess severity.
- Brand names
- Taxotere
- Other names
- Cisplatin, Carboplatin, Paclitaxel, Docetaxel
02
Targets
DNATUBB (Tubulin (alpha and beta subunits))
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